Unfortunately, diseases of the digestive tract, which are associated with violation of the normal secretion of hormones, are quite common in modern medicine.Esophagitis, ulcerative lesions of the stomach and intestines - an extremely unpleasant and dangerous diseases that require appropriate therapy.Of course, the choice of drugs that can help in the fight against such problems is enormous.
pretty effective medicine is considered "Konrolok."Instructions for use of the preparation is quite simple.According to statistics, this medication really helps to resolve some problems, so doctors often prescribe it to their patients exactly.But that part of the drug?What are the properties it possesses?Are there side effects?This information is of interest to many patients.
composition and the form of the drug
Medicine "Kontrolok" comes in two forms - a tablet and powder for solution.
can be purchased in a pharmacy tablet white, rounded, with a double shell.The main active substance is the preparation of
The tablets are packaged in blisters on the contour 5 or 7 pieces.One package may be from 1 to 3 such blisters.
Powder for solution sold in glass bottles.As in the previous case, the main components is pantoprazole sodium sesquihydrate.One vial contains 40 mg of active substance.In addition, the powder composition contains sodium hydroxide and disodium edetate.
About what form of medication is right for your case will tell the attending physician after a thorough inspection.
main pharmacological properties
main active ingredient of the drug is a proton pump inhibitor.This substance acts on the parietal cells of the mucosa, thereby inhibiting the synthesis processes of hydrochloric acid in the stomach.
After dissolution in gastric juice pantoprazole is transformed into an active form, and then blocks the final phase of the synthesis of hydrochloric acid.Thus, therapy with a decrease in acidity of gastric juice, which in turn leads to increased amounts of gastrin.By the way, if the treatment does not last long, the gastrin levels remained in the normal range.Prolonged therapy can lead to increased amounts of the substance is practically doubled.Only occasionally pills provoke active reproduction endocrine cells of the stomach, which leads to the development of adenomatoidnoy hyperplasia.
active components of the preparation are quickly absorbed tissues of the gastrointestinal tract.The maximum drug concentration in the blood observed after approximately 2 - 2.5 hours after administration of the tablet.Against the background of the level of long-term therapy of pantoprazole in the blood becomes permanent.Incidentally, the bioavailability of a drug does not depend on food intake.The active substance is 98% bound to plasma proteins.Drug metabolism occurs in the liver.Metabolic products medications by 80% the kidneys in the urine and 20% - along with stool.Incidentally, as compared with other proton pump inhibitors, active drug has greater chemical stability.It is allowed to take even patients with impaired kidney function.Metabolites of the drug in the body do not accumulate.
In some cases, the drug is appropriate reception "Kontrolok"?Instructions for use states that the drug is widely used to treat a variety of disorders associated with hypersecretory conditions.Also, the indication for use is Zollinger-Ellison Syndrome, reflux esophagitis and the presence of peptic ulcers in the stomach and duodenum intestine tissues.
Tablets "Kontrolok" with a dosage of 20 mg to effectively cope with mild reflux disease.The product effectively eliminates unpleasant symptoms such as heartburn and pain in the throat when swallowing.The same form of medication used to prevent stomach ulcers and intestine, especially in the case of patients who take nonsteroidal anti-inflammatory drugs for a long time.
But the tablets with a dosage of 40 mg successfully cope with more serious conditions, including peptic ulcer of the stomach and small intestine, and Zollinger-Ellison syndrome.Furthermore, in combination with antibacterial agents "Kontrolok" is used for treating lesions caused by the activity of the bacteria Helicobacter pylori.Also, the drug effectively cope with reflux of moderate and severe.
drug "Kontrolok": instructions for use
Immediately it is worth noting that only a specialist can prescribe the medicine.The dosage and duration of therapy is determined individually, so do not use the drug illegally "Kontrolok" (tablets).Instructions for use is simple, but it contains only general recommendations.
Typically, patients are advised to take one tablet a day, preferably in the morning, an hour before breakfast.Tablets should not be chewed, dissolve or grind - you need to take a sip of fully washed down with plenty of water.Mild disorder patients administered a daily dose of 20 mg.In more severe cases, the initial dose is 40 mg, but after the appearance of its improvements are gradually reduced.
duration of treatment also depends on the patient's condition.For example, duodenal ulcer take medication for two weeks.But with esophagitis, reflux and ulcerative lesions of the stomach take medication for four weeks.
When it comes to the treatment of infections Helicobacter Pylori, the daily dose can be increased up to 40-80 mg (one tablet sutra, the second - before dinner).When it comes to the treatment of severe or hypersecretory conditions Zollinger - Ellison, the initial daily dose can be increased to 160 mg pantoprazole (two tablets in the morning and two in the evening).But this is the maximum amount of drug and begin to phase out as soon as the first improvement.
Intravenous drug is indicated only in the case if, for one reason or another can not pills.Powder for solution in the vial is diluted with 0.9% sodium chloride or 5% glucose solution.The medicine is injected slowly, over 3-15 minutes.Incidentally, after preparing the solution must be used within three hours - after this time it can not be administered.
When it comes to the treatment of patients with hepatic insufficiency, it requires constant monitoring of liver enzymes.
Contraindications to therapy
Many people are interested in information about whether all categories of patients can take the drug "Kontrolok."Instructions for use indicates that the drug has some contraindications, although they are not so much.First, let's say about the age restrictions - tablets are not indicated for children who have not attained the age of twelve.
addition to contraindications include dyspepsia neurotic origin.It is relatively limited hepatic insufficiency - if necessary, patients with this diagnosis is still taking medicine, but under strict medical supervision.Of course, do not take medicine to people suffering from hypersensitivity to any of its components - Before use, always read the description of the composition.
We should also mention the treatment during pregnancy and lactation.Immediately it should be said that to date there is insufficient information on the effects of the drug on the child's body.However, doctors do not recommend taking these pills.The decision to hold such a treatment should be made solely by the attending specialist.
possible whether the complications and side effects?
Many patients are looking for more information about whether there can be dangerous pills "Kontrolok."Instruction indicates that there is a probability of occurrence of certain complications during therapy.On the other hand, in the medical practice cases of adverse events recorded rarely - not more than 5%.Nevertheless, should read the list of possible violations.
- In some cases, the drug can cause disorders of the digestive system.For example, patients sometimes complain of nausea, epigastric pain, and diarrhea, constipation, increased gas in the intestines.
- In some people, the drug "Kontrolok" can cause an allergic reaction.She is accompanied by the appearance of a skin rash, hives, itching.Very rarely during therapy develops increased photosensitivity, angioedema and erythema multiforme, Stevens-Johnson syndrome, Lyell's disease.
- Sometimes drug affects the functioning of the nervous system, which is accompanied by headaches, blurred vision and dizziness.Very rarely, patients suffering from disorientation, unexplained anxiety, hallucinations and depression.
- drug can cause elevated liver enzymes.Very rarely observed during therapy with hepatocyte damage, jaundice, and sometimes liver failure.
- Some patients have fever and the appearance of strong peripheral edema.These disorders tend to run on their own immediately after discontinuation of the drug.
- What else can cause adverse reactions drug "Kontrolok Control"?Instructions for use shows that occasionally during treatment people develop myalgias, and interstitial nephritis.
Once again it should be noted that the side effects are rare and in most cases are associated with the wrong medication.Furthermore, most of the complications disappear immediately after stopping and does not require any specific treatment.But in any case, the appearance of certain impairments should discontinue treatment and contact your doctor, telling all developed symptoms.
interactions with other drugs
course, is to try to find out all the information available before starting therapy with the drug "Kontrolok."Instructions for use, analogs, cost and reviews - this is very important.But it is also worth reading and the possible interaction of these pills with other drugs.
To start it is worth noting that the drug reduced absorption of the medication, the bioavailability of which depends on the level of acidity in the stomach (as an example, ketoconazole).And "Kontrolok" can not be used simultaneously with atazanavir.
In any case be sure to tell the reception your doctor about all medications you are currently taking to avoid possible complications.
What is medicine?
Today, many people are interested in questions about what constitutes a drug "Kontrolok."Instructions for use, medication reviews, as well as contraindications and possible side effects - it is extremely important information.But many consumers do not less important is the value of a given drug.
Immediately it is worth noting that prices will fluctuate depending on the city you live, the manufacturer of the drug, the pharmacy fiscal policy, the selected dosage and number of tablets.For example, the cost of one bottle for the preparation of solutions is around 200-300 rubles.Package of 14 tablets with a dosage of 20 mg - 750-800 rubles.But the drug at a dose of 40 mg is more expensive - the price varies from 950 to 1200 rubles.
Are there effective analogs?
Not all patients are suitable the drug.For some people, there is increased sensitivity to others as a full course of treatment simply can not afford.What to do in such cases?What can replace the medicine "Kontrolok"?Analogs of the drug, of course, exist.Moreover, there are means of different price categories, with a different composition, but the same effect.
most popular drug substitutes "Kontrolok" - "Nolpaza" and "Zolopent."In addition, they are considered sufficiently effective "Pantazi", "Proksium", "Ultera" and "Tektite control", "pantoprazole" and "Call".Any of these means can be easily found at any drugstore.
But it is understood that you can not arbitrarily cancel the reception of the drug "Kontrolok."Analogs may appoint only doctor, so be sure to consult with him about it.The specialist will also help to choose the most effective dosage and determine the course of treatment.
«Kontrolok" or "Nolpaza": which is better?
As you can see, the drug has a large number of peers.Today, many patients are interested in the question of what is more effective - "Kontrolok" or "Nolpaza"?What better eliminates the symptoms?What is safe for health?
Immediately it is worth noting that "Nolpaza" is a direct analogue, but from the other (Slovene) of the manufacturer.The main active ingredient is the same patoprazol.And, according to the rating patients, these tablets also effectively eliminate all symptoms of gastrointestinal disorders, and help normalize the digestive system.Some doctors argue that treatment with "Nolpazoy" more likely to experience side effects.On the other hand, this drug has a definite advantage - it is much cheaper.For example, packing "Nolpazy" of 14 tablets with a dose of 20 mg costs only 150-180 rubles.The same number of tablets with a dosage of 40 mg will cost about 300 rubles.You agree that the price difference is palpable.Therefore, many patients choose this drug.
Reviews patients and physicians
Today, doctors recommend it to many patients the drug "Kontrolok."Reviews - this is another source of valuable information, so readers are primarily interested in the views of the experts and those patients who have received treatment.
Doctors mostly positive about this preparation.Indeed, it helps eliminate the unpleasant symptoms and, along with it gradually normalize liver enzymes, thereby eliminating the root cause of the disease.Side effects are rare, so the drug can be called even bezlopasnym.
What do patients say about tablets "Kontrolok"?Reviews curing as the majority are positive.Indeed, the treatment helps to eliminate a lot of problems.The tablets conveniently take, and only once per day.Some patients say that the symptoms persist after the first administration, tablets (eg, heartburn is).This is normal, as the drug has a systemic influence - it is not simply neutralize the acidic environment, it normalizes the synthesis of enzymes and hydrochloric acid, and it takes some time.
Some patients say that heartburn, pain in the stomach, and other symptoms appear again immediately after discontinuation of the drug.The fact that the drug should be stopped drinking gradually reducing the dose of the day by day.Abrupt withdrawal of the drug leads to the same sharp increase gastric acidity.
Another drawback of the drug is its relatively high cost.Indeed, you can find cheaper counterparts.Nevertheless, it is a medicine of the German production is considered one of the most effective and safe, so it's worth the money spent.